1.Fosslien E. Cancer morphogenesis: role of mitochondrial failure. Ann Clin
Lab Sci. 2008 Autumn;38(4):307-29.
2. Auger C, Alhasawi A, Contavadoo M, et al. Dysfunctional mitochondrial bioenergetics and the pathogenesis of hepatic disorders. Front Cell Dev Biol. 2015 Jun 25;3:40.
3. Lim, S, Cho YM, Park KS, et al. Persistent organic pollutants, mitochondrial dysfunction, and metabolic syndrome.Ann N Y Acad Sci. 2010 Jul;1201:166-76.
4. Jia G, Aroor AR, Martinez-Lemus LA, et al. Mitochondrial functional impairement in reponse to environmental toxins in the cardiorenal metabolic syndrome. Arch Toxicol. 2015 Feb;89(2):147-53.
5. Lee HK. Mitrochondrial dysfunction and insulin resistance: the contribution of dioxin-like substances. Diabetes Metab J. 2011 Jun;35(3):207-15.
6. Ferguson LR, Philpott M, Karunasinghe N. Dietary cancer and prevention using antimutagens. Toxicology. 2004 May 20;198(1-3):147-59.
7. Williams DE. The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention. Comp Biochem Physiol C Toxicol Pharmacol. 2012 Jan;155(1):121-7.
8. Nagini S, Palitti F, Natarajan AT. Chemopreventive potential of chlorophyllin: A review of the mechanisms of action and molecular targets.Nutr Cancer. 2015;67(2):203-11.
9. Available at: http://www.mountsinai.org/patient-care/serviceareas/children/areas-of-care/childrens-environmental-healthcenter/childrens-disease-and-the-environment/children-and-toxicchemicals (http://www.mountsinai.org/patient-care/serviceareas/children/areas-of-care/childrens-environmental-healthcenter/childrens-disease-and-the-environment/children-and-toxicchemicals) .Accessed September 11, 2015.
10. Thornton JW, McCally M, Houlihan J. Biomonitoring of industrial pollutants:health and policy implications of the chemical body burden. Public Health Rep. 2002 Jul-Aug;117(4):315-23.
11. Available at: http://www.cdc.gov/exposurereport/(http://www.cdc.gov/exposurereport/). Accessed September 11, 2015.
12. Available at: http://www.cdc.gov/biomonitoring/BisphenolA_FactSheet.html(http://www.cdc.gov/biomonitoring/BisphenolA_FactSheet.html ). Accessed September 11, 2015.
13. Calafat AM, Wong LY, Kuklenyik Z, at al. Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000.Environ Health Perspect. 2007 Nov;115(11):1596-602.
14. Steenland K1, Zhao L, Winquist A, et al. Ulcerative colitis and perfluorooctanoic acid (PFOA) in a highly exposed population of community residents and workers in the mid-Ohio valley. Environ Health Perspect. 2013 Aug;121(8):900-5.
15. Watkins DJ, Josson J, Elston B, et al. Exposure to perfluoroalkyl acids and markers of kidney function among children and adolescents living near a chemical plant. Environ Health Perspect. 2013 May;121(5):625-30.
16. Lopez-Espinosa MJ, Mondal D, Armstrong B, et al. Thyroid function and perfluoroalkyl acids in children living near a chemical plant. Environ Health Perspect. 2012 Jul;120(7):1036-41.
17. Barry V, Winquist A, Steenland K. Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant. Environ Health Perspect. 2013 Nov-Dec;121(11-12):1313-8.
18. Gouda EM, Elbehairy AM, Ghoneim MA. Antimutagenic efficacy of some natural compounds on cyclophosphamide-induced p53 alterations. Z Naturforsch C. 2008 Nov-Dec;63(11-12):857-63.
19. Hayatsu H. Complex formation of heterocyclic amines with porphyrins: its use in detection and prevention.Princess Takamatsu Symp. 1995;23:172-80.
20. John K, Keshava C, Richardson DL, et al. Immune Response Signatures of Benzo(α)pyrene Exposure in Normal Human Mammary Epithelial Cells in the Absence or Presence of Chlorophyllin. Cancer Genomics Proteomics. 2009 Jan-Feb;6(1):1-11.
21. Lagerqvist A1, Håkansson D, Frank H, et al. Structural requirements for mutation formation from polycyclic aromatic hydrocarbon dihydrodiol epoxides in their interaction with food chemopreventive compounds. Food Chem Toxicol. 2011 Apr;49(4):879-86.
22. John K, Divi RL, Keshava C, et al. CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin. Cancer Lett. 2010 Jun 28;292(2):254-60.
23. Mata JE, Yu Z, Gray JE, et al. Effects of chlorophyllin on transport ofdibenzo(a, l)pyrene, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine,and aflatoxin B(1) across Caco-2 cell monolayers. Toxicology. 2004 Mar1;196(1-2):117-25.
24. Hirose M, Nishikawa A, Shibutani M, et al. Chemoprevention ofheterocyclic amine-induced mammary carcinogenesis in rats. Environ MolMutagen. 2002;39(2-3):271-8.
25. Vidya Priyadarsini R, Kumar N, Khan I, et al. Gene expression signature of DMBA-induced hamster buccal pouch carcinomas: modulation by chlorophyllin and ellagic acid. PLoS One. 2012;7(4):e34628.
26. Konickova R, Vankova K, Vanikova J, et al. Anti-cancer effects of bluegreen alga Spirulina platensis, a natural source of bilirubin-like tetrapyrrolic compounds. Ann Hepatol. 2014 Mar-Apr;13(2):273-83.
27. Chimploy K, Diaz GD, Li Q, et al. E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. International journal of cancer. Int J Cancer. 2009 Nov 1;125(9):2086-94.
28. Lihuan D, Jingcun Z, Ning J, et al. Photodynamic therapy with the novel photosensitizer chlorophyllin f induces apoptosis and autophagy in human bladder cancer cells. Lasers Surg Med. 2014 Apr;46(4):319-34.
29. Smith WA, Freeman JW, Gupta RC. Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7. Mutat Res. 2001 Sep 1;480-481:97-108.
30. Thiyagarajan P, Kavitha K, Thautam A, et al. Dietary chlorophyllin abrogates TGF-beta signaling to modulate the hallmark capabilities of cancer in an animal model of forestomach carcinogenesis. Tumour Biol. 2014 Jul;35(7):6725-37.
31. Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental health perspectives. Environ Health Perspect. 2010 Jun;118(6):818-24.
32. Jubert C, Mata J, Bench G, et al. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer Prev Res (Phila). 2009 Dec;2(12):1015-22.
33. Egner PA, Wang JB, Zhu YR, et al. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14601-6.
34. Kamat JP, Boloor KK, Devasagayam TP. Chlorophyllin as an effective antioxidant against membrane damage in vitro and ex vivo. Biochim Biophys Acta. 2000 Sep 27;1487(2-3):113-27.
35. Boloor KK, Kamat JP, Devasagayam TP. Chlorophyllin as a protector of mitochondrial membranes against gamma-radiation and photosensitization. Toxicology. 2000 Nov 30;155(1-3):63-71.
36. Zapico SC, Ubelaker DH. Relationship Between Mitochondrial DNA Mutations and Aging. Estimation of Age-at-death. J Gerontol A Biol Sci Med Sci. 2015 Aug 18.
37. Dai DF, Chiao YA, Marcinek DJ, Szeto HH, Rabinovitch PS. Mitochondrial oxidative stress in aging and healthspan. Longev Healthspan. 2014 May 1;3:6.
38. Ross JM, Olson L, Coppotelli G. Mitochondrial and ubiquitin proteasome system dysfunction in ageing and disease: two sides of the same coin? Int J Mol Sci. 2015 Aug 17;16(8):19458-76.
39. Smith RJ. Nutrition and metabolism in hepatocellular carcinoma. Hepatobiliary Surg Nutr. 2013 Apr;2(2):89-96.
40. Kar P. Risk factors for hepatocellular carcinoma in India. J Clin Exp Hepatol. 2014 Aug;4(Suppl 3):S34-42.
41. Nault JC. Pathogenesis of hepatocellular carcinoma according to aetiology. Best Pract Res Clin Gastroenterol. 2014 Oct;28(5):937-47.
42. Nogueira L, Foerster C, Groopman J, et al. Association of aflatoxin with gallbladder cancer in Chile. JAMA. 2015 May 26;313(20):2075-7.
43. Cui A, Hua H, Shao T, et al. Aflatoxin B1 induces Src phosphorylation and stimulates lung cancer cell migration.Tumour Biol. 2015 Aug;36(8):6507-13.
44. Sieber SM, Correa P, Dalgard DW, Adamson RH. Induction of osteogenic sarcomas and tumors of the hepatobiliary system in nonhuman primates with aflatoxin B1. Cancer Res. 1979 Nov;39(11):4545-54.
45. Moulton PV, Yang W. Air pollution, oxidative stress, and Alzheimer’s disease. J Environ Public Health. 2012;2012:472751.
46. Pan-Montojo F, Reichmann H. Considerations on the role of environmental toxins in idiopathic Parkinson’s disease pathophysiology. Transl Neurodegener. 2014 May 9;3:10.
47. Kim NH, Hyun YY, Lee KB. Environmental heavy metal exposure and chronic kidney disease in the general population. J Korean Med Sci. 2015 Mar;30(3):272-7.
48. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22.
49. Barja G. Free radicals and aging. Trends Neurosci. 2004 Oct;27(10):595-600.
50. Junqueira VB, Barros SB, Chan SS, et al. Aging and oxidative stress. Mol Aspects Med. 2004 Feb-Apr;25(1-2):5-16.
51. Ashok BT, Ali R. The aging paradox: free radical theory of aging. Exp Gerontol. 1999 Jun;34(3):293-303.
52. Available at:
http://deainfo.nci.nih.gov/advisory/pcp/annualReports/pcp08-09rpt/PCP_Report_08-09_508.pdf ). Accessed September 14, 2015.
53. Erkekoglu P, Kocer-Gumusel B. Genotoxicity of phthalates. Toxicol Mech Methods. 2014 Dec;24(9):616-26.
54. Kuppusamy SP, Kaiser JP, Wesselkamper SC. Epigenetic Regulation in Environmental Chemical Carcinogenesis and its Applicability in Human Health Risk Assessment. Int J Toxicol. 2015 Aug 12.
55. Van Vleet TR, Watterson TL, Klein PJ, et al. Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells. Toxicol Sci . 2006 Feb;89(2):399-407.